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Karyopharm Therapeutics Inc. Senior Vice President, Strategy and Portfolio Management in Newton, Massachusetts

SUMMARY: The SVP, Strategy and Portfolio Management, will be responsible for providing strategic and analytic leadership across all areas of R&D pipeline strategy and management including identifying asset-level, research/early stage portfolio interactions and implications as well as highlighting gaps and making recommendations. The VP, Strategy and Management will provide pipeline and strategic expertise to all members of the R&D senior leadership team. Additionally, The SVP, Strategy and Portfolio Management will lead and manage a team of Program Leaders.


  • The SVP, Strategy and Portfolio Management, will provide high level oversight, management and drive across the span of development from strategy formulation to execution of that strategy; this encompasses the entire process from preclinical research through registration.

  • The Strategy and Portfolio Management team will coordinate between all internal/external stakeholders (e.g. Clin Ops, Medical, Pre-clinical, PIs, MSLs, Regulatory, Research, Drug supply, Publications as well as Investigators, Patient groups) to ensure alignment, operational efficiency and program success.

  • Creates and supports a consistent, linked strategic framework across early and late stage assets to enable strategic decision-making—including strategic context setting, decision structuring, risk assessment, value profiles, governance preparation, etc.

  • Provides direction on product development requirements to meet expectations of external customers and business stakeholders. Interacts with research and development, marketing, manufacturing, and regulatory departments and with external stakeholders.

  • Provides strategic leadership and expertise with respect to decision making--providing real-time evaluation and identification of material events, critical analysis of problems and utilization of insights.

  • Monitors pipeline progress and industry benchmarking data, identifies trends, risks and gaps and recommends specific strategies to enhance/optimize KPTI’s pipeline. Drives pipeline review events, processes and deliberations including scenario planning and trade-off decisions

  • Partners directly with governance members and senior leaders to ensure preparation, implementation and follow-up of scientific and pipeline-related decisions and actions.

  • Drives synchronization and harmonization of inputs, outputs and processes across R&D governance and other pipeline related forums with a goal of streamlining and enhancing stakeholder experience associated with the pipeline governance and evaluation/management process. Specific responsibilities include chairing of forums, agenda curation and executive communications.

  • Responsible for project performance, risk management, administration, financial management and issue resolution for functional group

  • Advanced science degree (such as MD, DO or PhD) required. MD strongly preferred.

  • Minimum 15 years of experience in R&D or commercial business and/or corporate planning in life sciences industry.

  • Pharmaceutical Industry Acumen – ability to define, develop and implement business solutions based on trends, opportunities, needs and market direction within pharmaceutical industry and health care environment.

  • Willingness to travel domestic and internationally to attend various meetings or other sites

  • Familiarity with portfolio assessment and optimization techniques, with an ability to articulate the pros and cons of various approaches and demonstrated ability to modify and adapt a suite of existing or available tools and techniques to fulfil business objectives.

  • Deep understanding of the drug development process as well as asset valuation.

  • Ability to synthesize information from multiple sources, communicate ideas and data both verbally and written in a persuasive and appropriate manner in multi-cultural environment.

  • Analytical Skills – ability to analyze a wide variety of data, including benchmarking data and financial figures to make strategic decisions.

  • Experience presenting to and interacting with Senior Executives in R&D and Commercial organizations in Life Sciences.

  • Ability to articulate and establish processes which impact cross-functionally

  • Proactive ability to predict issues and problem solve

  • Ability to drive/influence decision making across all levels of the organization.

  • Proven financial, budget and resource planning experience.

Karyopharm Therapeutics is an innovation driven pharmaceutical company focused on the discovery, development, and commercialization of medicines with the goal of improving the lives of patients with cancer and other major diseases.

ID: 2020-1604

Street: 85 Wells Ave.