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Karyopharm Therapeutics Inc. Senior Director, Alliance Management in Newton, Massachusetts

The Senior Director of Alliance Management is responsible for maximizing the value of each collaboration with the mindset of creating mutual win-wins while managing risk to Karyopharm. The Senior Director of Alliance Management will play an important role in supporting Karyopharms global partnering activities and Alliance Capability buildout. This individual will be responsible for leading one or more multi-country, development, and commercialization Alliances. This role will report into the Executive Director, Head of Alliance Management at Karyopharm.

  • Provide Alliance leadership, coordination, and oversight

  • Develops a fit for purpose governance infrastructure per alliance and lead the implementation to ensure transparent decision making across the collaboration

  • Ensure internal and partner alignment on development and commercialization strategies with supporting tactical execution

  • Manage contractual obligations and making the contract come “alive” across organizations through a detailed understanding of the contractual obligations

  • Provides a single point-of-contact for partners and a pathway for resolution of business and issue resolution

  • Proactively manage human risks, financial risks, and Alliance disputes

  • Provide Alliance reporting and reviews to senior management

  • Perform periodic Alliance Health checks and implement plan to address gaps

  • Support the organizational Alliance Capability build-out

  • Proactively seek opportunities to expanding existing partnerships

  • Bachelor’s degree required. MS or MBA preferred

  • 10+ years’ experience in the biotech / pharmaceutical industry

  • Success record of managing global strategic partnerships throughout the partnering lifecycle from launch to wind-down

  • In depth working knowledge of clinical development, manufacturing, supply, regulatory, and commercialization processes including launches

  • Proven program and project management knowledge and skills

  • Proven negotiation capabilities and mindful conflict resolution

  • High degree of personal integrity, strong ability to work collaboratively and effectively cross-functionally

  • Strong interpersonal and communications skills driving confidence internally and externally

  • Demonstrated leadership capabilities and executive presence

  • Pro-active, well organized, and sound business judgment

  • Excellent abilities to build professional relationships internally and externally

Karyopharm Therapeutics Inc. (NASDAQ: KPTI) is a commercial-stage pharmaceutical company pioneering novel cancer therapies and dedicated to the discovery, development, and commercialization of first-in-class drugs directed against nuclear export for the treatment of cancer and other diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharm's lead compound, XPOVIO® (selinexor), is approved in the U.S. in multiple hematologic malignancy indications, including in combination with Velcade® (bortezomib) and dexamethasone for the treatment of adult patients with multiple myeloma after at least one prior therapy, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma and as a monotherapy for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. NEXPOVIO® (selinexor) has also been granted conditional marketing authorization in combination with dexamethasone for adult patients with heavily pretreated multiple myeloma by the European Commission. In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. For more information, please visit

Karyopharm Therapeutics Inc. (the "Company") is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law. Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities. If you require an accommodation in the application process, please contact a member of the Company’s Human Resources department.

ID: 2021-1854

Street: 85 Wells Ave.