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Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

This position is based in Cambridge, MA. Remote work from certain states may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.

Purpose and Scope:

Lead the development and execution of Translational Medicine strategy in development of Astellas’ assets. Candidates should have record of accomplishment of developing and executing translational science/medicine programs with mechanistically grounded biomarker and patient selection strategies. Ability to work in cross-functional teams is essential to the success of this position.

Essential Job Responsibilities:

• Develops and executes translational science and biomarker development plans and define patient selection strategies for clinical studies

• Provides key specifics on the mechanism of action, biomarker identification and patient selection strategies

• Contributes to overall development strategy and trial design, incorporating biomarker endpoints

• Works with clinical team for implementation of biomarker sample collection and bioanalysis

• Drives clinical biomarker data analysis and interpretation

• Contributes to clinical documents: protocols, IBs, study reports, statistical analysis plans, publications, CSR and biomarker sections of regulatory submissions

• Leads reverse translation, so that clinical results can be used to inform development strategy

• Contributes to greater understanding of the mechanism of action to enable clinical translation

• Thinks strategically and drives innovation. Identifies and leads the evaluation of state -of- the- art technologies for translational and biomarker research

• Establishes and leads Translational Medicine focused external collaborations

Qualifications:

Required

• Advanced science degree (PhD, PharmD, or MD) with primary focus in Oncology

• A minimum of 10 years relevant experience in drug discovery and development in biotech/pharmaceutical company or equivalent translational research experience at an academic institution.

• Breadth of knowledge in cancer biology, cancer genomics, and oncology drug development

• First-hand experience in the identification and validation of pharmacodynamic and patient selection biomarkers, biomarker assay qualification and clinical implementation

• Proven record of leading teams and obtaining high quality and timely results through influencing in a matrix environment

• Demonstrated success in delivering high quality clinical biomarker data to inform decisions and development strategy

• Broad technical experience in DNA, RNA, and protein-based biomarker assays (e.g. PCR, NGS, ELISA/MSD, IHC)

• Experience in fit-for-purpose biomarker assay qualification/validation

• An innovation mindset with track record of incorporating new technologies in translational and biomarker research

• Strong communication skills (oral, written, and presentations), interpersonal, influencing, and overall leadership skills

Preferred:

• Experience in developing and managing academic collaboration and CRO work

Salary Range

$190,000K – $240,000K (NOTE: Final salary could be more or less, based on experience)

Benefits:

• Medical, Dental and Vision Insurance

• Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

• 401(k) match and annual company contribution

• Company paid life insurance

• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

• Long Term Incentive Plan for eligible positions

• Referral bonus program

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Category Translational Medicine

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans