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Alexion Pharmaceuticals Portfolio Analytics Lead in Boston, Massachusetts

Some opportunities happen only once in a lifetime - like a job where you have the chance to change lives. At Alexion, people living with rare and devastating diseases are our Guiding Star. We are driven to continuously innovate and create meaningful value in all we do to help patients and families fully live their best lives. We value the uniqueness and diversity of our employees and recognize that nurturing the diverse perspectives and strengths of our people translates into innovative breakthroughs for patients.

This is what you will do:

At Alexion, AstraZeneca Rare Disease, we are innovators, leaders, and collaborators. At the heart of everything we do is an intense desire to pursue the toughest challenges and truly change the world for people living with rare and devastating diseases.

The VISion team (Value, Insights Strategy at Alexion) is a fully integrated commercial strategy team, aligning global marketing, new product planning, and commercial excellence across all therapeutic and disease areas. The purpose of VISion is to partner with both global colleagues (R&D, Operations, Corporate Affairs, Finance, et al) and regional and local Commercial colleagues to ensure the successful development and launch of innovative therapies that will deliver value for all our stakeholders. Our unique culture is centered on collaboration, authenticity, creativity and pushing the boundaries on everything we do to advance patient care.

The Portfolio Analytics Lead conducts robust portfolio forecasting and reporting capabilities to define financial opportunities for the pipeline which aid in enterprise-wide portfolio decision making. This position will support assessment of internal and external opportunities, including rationale, technical and commercial considerations, in partnership with key organization stakeholders. As such, the ideal candidate is highly collaborative and confident interfacing with senior and middle management (Global Program Leaders and team members, regional Commercial management, and Therapeutic Area management and team members) on internal governance interactions.

The key focus of this role is to provide financial and analytical support and oversight and produce long-term topline and patient forecasting to enable data-driven decision making (integrated with market insights), demand and infrastructure planning, and deeper comprehension of underlying commercial opportunities. This work will include the development of strategic business cases, scenarios, and inputs into portfolio prioritization.

You will be responsible for:

  • Lead revenue forecasting across pipeline indications and beyond the mid-term period for in-line products.

  • Lead annual processes related to portfolio assessment, long-term planning, management, and prioritization for Alexion portfolio, including analyzing changes with respect to prior evaluations.

  • Facilitate cross-functional discussions at program and portfolio level to influence program level strategic and forecasting discussions, provide portfolio view and cross-product knowledge, and generate alignment on company long-term strategic plans.

  • Serve as a strategic partner with Therapeutic Area Leads, GPTs, and appropriate functions to acquire data and incorporate business intelligence to develop, align and present key assessments to support executive level strategic decisions across internal portfolio.

  • Integrate insights from functional expertise spanning epidemiology, market research, competitive intelligence, market access, and others.

  • Develop and use models for scenario planning with a variety of decision frameworks, draw insight from these models, and present and explain them to stakeholders.

  • Collaborate closely with Finance to project long range financials, valuation and capital needs; provide Finance with all necessary revenue inputs for their consolidation, analysis and management reporting of long- and mid-term planning.

  • Ensure data integrity and provide ad-hoc and standard reports and presentations to management; identify variations from prior strategic plans and operational planning; provide information around potential consequences and recommendations for corrective actions.

  • Maintain relevant knowledge of external market landscape, pipeline, and competition in core therapeutic areas.

  • Drive optimization and continuous improvement of strategic portfolio and financial planning processes, systems, and operational excellence in partnership with the CFO team.

    You will need to have:

  • Bachelor Degree in Business/Finance, MBA preferred; is a strong plus

  • At least 6 years of experience in biopharmaceutical industry, with experience in one or more of the following areas: strategic planning, corporate development/business development, business analytics, market research, finance/controlling or management consulting

  • Previous experience in leading processes spanning long term business planning, portfolio analytics and portfolio prioritization supporting Pharmaceutical R&D pipeline and Business Unit/Regional Unit P&L analysis, including detailed sales forecasting, cost analysis and project economic evaluation

  • Exceptional quantitative and analytical modeling skills with an ability to translate complex business questions into financial models

  • The ability to manipulate heavy sets of data, including building and updating discounted cash flow and technical probability assessment

  • Mastery of Excel and modeling software

  • Ability to think strategically about current portfolio and future evolution in the context of competition and external trends

  • Strong analytical and operational capability, with ability to manage projects and timelines; effective stakeholder management skills

  • Strong written and verbal communication skills; ability to produce high-quality, impressive deliverables that are suitable for senior executive audience

  • Highly collaborative, strong interpersonal skills and cross-functional team experience; ability to lead and influence within a matrix

  • Willingness to travel (domestic, international) 10% of the time, in accordance with company policies

  • The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

    We would prefer for you to have:

  • Experience analyzing and developing economic proposals for external innovation, including licensing and acquisition opportunities.

  • Scientific background is a plus.

  • Direct experience performing a similar role in-house or in consulting.


Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at:

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, parental status (including adoption or surrogacy), pregnancy (including childbirth, breastfeeding, or related medical conditions), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact Alexion participates in E-Verify.

As a leading employer in our industry, Alexion offers a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more.

AstraZeneca completed its acquisition of Alexion, marking the creation of Alexion, AstraZeneca Rare Disease. If you're interested in career opportunities with AstraZeneca, click here ( .