Shire Product Medical Lead IG, Global Medical Affairs Immunology and HAE in Cambridge, Massachusetts

 Work with the Sr Director, Franchise Medical Team Lead IG, to develop and execute multi-year global medical strategy for the specified Product/Disease Area, appropriately aligned with overall strategy and incorporating R&D functional strategies (clinical, regulatory, HEOR, PV, compliance)

 Work with the Franchise Medical Team Lead on the development and in-year implementation of Global Medical plans and Country specific Launch plans for new products or indications in collaboration with US Medical Affairs and International Medical Affairs

 Drives global execution, support, and coordination of specific medical projects per global Medical strategy, including engagement of and partnership with Country Medical colleagues

 Serve as Global Medical representative on standing and project-based cross-functional teams

 As needed, provide Medical review to Global promotional and non-promotional materials

 Act as a company representative interacting with external scientific leaders, patient advocacy groups and/or regulatory authorities

 Establish appropriate strategic partnerships with centers of excellence and KOLs in areas of scientific interest


% of Time

Job Function and Description


Support definition of global medical strategy and plans

  • Work with the Franchise Medical Team Lead and Global Medical Affairs Team to develop medical strategy, including e.g. in-line R&D LCM strategy, publications strategy, congress strategy, customer interaction strategy, and the scientific communication platform for the disease area / brand(s), aligned with product strategy

  • Support development of the in-year medical tactical plan and budget for the global initiatives and the United States

  • As delegated by the Franchise Medical Team Lead, lead functional (e.g. publications, medical communications, medical training) and in-line R&D teams in developing plans supporting global medical strategy

  • As delegated by the Franchise Medical Team Lead, collaborate with commercial to ensure aligned and medically appropriate commercial strategy, planning and execution.

  • As delegated by the Franchise Medical Team Lead, participate in development of product strategy; provide medical affairs and R&D inputs for product(s) to Product Strategy Team


Work with Franchise Medical Team Lead on in-year implementation of global medical strategy

As delegated by the Franchise Medical Team Lead, directly implement in plans in the Countries/ Regions in-year implementation of Medical Strategy and Country launch plans, potentially including:

  • Providing physician leadership for scientific communications, including standard responses and publications

  • Planning, designing and managing global and overseeing regional/local medical Advisory Boards

  • Providing medical review of Investigator Initiated Research (IIR) proposals and other grants through the grant approval process

  • Supporting the management, design and execution of clinical studies (phase IIIb/IV, disease registries, epidemiological studies, outcomes surveys, etc.) in close collaboration with Therapeutic Area Clinical Development head and Global Clinical Operations

  • Managing completion of regulatory obligations

  • Monitoring and communicating progress against medical plan; propose and initiate initiatives as need to adjust to disease area requirements

  • Conducting medical review and approval of promotional and meeting materials

  • Serving as Global Medical representative on standing and project-based cross-functional teams


Interaction with external stakeholders in alignment with customer needs and medical strategy

  • Act as a company representative with external scientific leaders, policy makers, patient advocacy groups and/or regulatory authorities

  • Per medical strategy, establish and/or enhance partnerships with key academic institutions and develop relationships with key thought leaders

  • Per medical strategy, establish appropriate partnerships with KOLs in areas of scientific interest

  • Represent Global Medical Affairs at internal and external meetings

  • Present data on product / therapeutic area


Maintenance of knowledge base

  • Serve as a key medical resource on the disease area and on specific products

  • Maintain a high level of expertise on the disease area

  • Develop and maintain knowledge of global pharmaceutical regulations, guidelines, codes of practices and Shire policies related to all medical activities

  • As directed by the FRANCHISE MEDICAL TEAM LEAD, develop, conduct, or participate in therapeutic training programs for Shire internal departments

Education and Experience Requirements

  • A medical degree or scientific degree (PhD or Pharm D) is required

  • 8-10 years of experience in biopharmaceutical medicine, preferably within a matrix or franchise structure.

  • Experience in Medical Affairs is required

  • Experience leading project teams at the brand or disease area levels in country, regional or global organizations is preferred

  • Experience in field-based roles (e.g. Medical Director, Medical Science Liaison) is preferred

  • Experience in clinical development is preferred

  • Experience in the disease area of interest through clinical experience, biopharmaceutical experience or education is preferred

Key Skills, Abilities, and Competencies

  • Demonstrated business acumen and operational skills

  • Ability to think strategically and tactically from a medical perspective about how to medically appropriately support the growth of a brand

  • Ability to work in a Global environment, across diverse cultures

  • Ability to collaborate appropriately with Commercial functions

  • Ability to represent company’s interest in scientific forums as needed

  • Excellent written and verbal communication skills

  • Ability to manage teams and drive initiatives without direct line management authority

  • Results orientation and accountability

  • Good analytical skills as applied to medical, scientific and technical information

  • Unquestioned ethics are a must

Complexity and Problem Solving

  • Management of discrete medical projects

  • Representation of GMA and contribution to a range of internal functional groups

  • External stakeholder management and engagement

Internal and External Contacts

  • Position is accountable to Franchise Medical Team Lead

  • Internal: Member Global Medical Team

  • Internal: US Field Medical Team Lead and team, International Medical Affairs team, GMA SME teams, Regulatory, Compliance, Legal, Late-stag Team

  • External: Academic, professional, regulatory, policy, patient advocacy leaders, strategic vendor partners

Other Job Requirements

  • Availability to travel approximately 30% of time

  • Some activities may call for early or late meetings and attendances at scientific meetings on holidays and weekends

Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.