Shire Global Program Management Lead in Cambridge, Massachusetts

The Global Program Management Lead (GPM) position is a high impact, leadership role responsible for key elements of program strategy and cross-functional execution within Shire’s Early-stage Global Product Team (EPT) or Late-stage Global Product Teams (LPT). The GPM role requires a talented individual with proven expertise in leading cross-functional teams and driving product strategy, planning and program execution. The GPM, in partnership with the Global Development Lead (GDL) and Product Strategy Lead (PSL), will drive program management and ensure clear and timely communication of program strategy, implementation plans and program progress. The GPM together with the GDL in the EPT or the GDL and PSL in the LPT will work to ensure the cross-functional teams operate effectively with positive global team dynamics driving product development. As a team member of the EPT/LPT, the GPM is expected to be knowledgeable about the overall development program in order to be strategic in planning, program progress oversight, communication and process management. The GPM achieves this by delivering high quality program management expertise, leadership and other high value services that support the team and improve the probability of program success.

The GPM, together with the GDL and PSL, provides the strategic vision and guides the team in developing integrated plans to successfully execute the strategy. The GPM will be responsible for one or more programs with clearly defined objectives.

The GPM will:

  • Coordinate and drive development process planning activities of the EPT/LPT including Integrated Development Plans, Long Range Plan, budget inputs and go/no go criteria as appropriate.

  • Work closely with the GDL/PSL to facilitate the elaboration, approval and execution of the global program strategy, as well as facilitate the decision-making process for their development program(s)

  • Work independently to provide best-in-class operations and program management expertise to drive EPT/LPT members towards excellence in execution.

  • Maintain the overall development plans and enterprise R&D portfolio inputs

  • Collaborate with GDL, PSL and EPT/LPT functional team members to ensure coordinated evaluation of product opportunities and/or scenarios and development of comprehensive, integrated recommendations (e.g. to Governance Committees) and strategic and operational product plans based on program defined objectives. Facilitate collection, alignment and validation of LPT sales and marketing budget ensuring alignment to LPT strategy

  • Facilitate preparations and analyses of LPT business reviews, goal setting and routine evaluation processes, and progress against LPT strategy and action plans

  • Execute and drive the annual planning processes from a LPT perspective, i.e. Product Strategy, Lifecycle Management, Strategic Product Plans, Brand Plans, Budgeting, Long Range Planning in partnership with GDL and PSL.

  • Lead and facilitate cross-functional team meetings (agendas, minutes, tracking actions, etc.)

  • Facilitate team goal setting and tracking to ensure adherence to plan and strategy, and end of year team evaluation process

  • Coordinate EPT/LPT communications to ensure team member alignment

  • Issue and present reports to senior management on a routine basis

  • Provide clear direction on product development requirements to meet expectations of external customers and business stakeholders

  • Be responsible for making decisions regarding the appropriate risk when there is substantial program impact

  • Lead other cross-functional projects (either strategic and/or operational) required by R&D GPM.

Reinforce team operating principles to maximize alignment within the team and with other functions.



EPT/LPT Strategy / Operations / Program Management


R&D Program Management Processes and R&D Initiatives

Education and Experience Requirements

  • Minimum of 8-10 years of experience in drug development in a pharmaceutical environment

  • Minimum of 5 years of cross-functional program management experience in managing a diversity of therapeutic areas and multiple stages of development and commercialization of prescription drug products (Phase 1 through launch).

  • Demonstrated ability to manage complex cross-functional teams and processes

  • Strong understanding of the business environment and relevant key strategic and operational drivers.

  • Strong knowledge and understanding of global product development and commercialization in the pharmaceutical industry

  • Demonstrated ability to work without routine supervision to deliver key accountabilities

  • Strong understanding and competency in planning processes and decision making

  • Demonstrated experience using standard program management tools and software including integrated development plans, timelines, risk management, and budget development and monitoring.

  • Training, coaching and leadership experience

  • Project Management Professional (PMP) certification or equivalent proficiency a plus

  • Demonstrated finance and business acumen

  • Bachelor’s degree in life sciences or related field required; Advanced degree in life sciences or MBA preferred

Key Skills, Abilities, and Competencies

  • High level of accountability

  • Able to translate strategies into tangible deliverables for team to execute

  • Independent and creative thinker requiring minimum oversight

  • Strong influencing and interpersonal skills including negotiation, managing meetings and group dynamics, ability to balance concerns of line management with objectives of cross-functional team

  • Strong influencing without authority skills

  • Management and leadership of complex projects

  • Strong analytical and decision-making ability, including ability to synthesize complex and diverse inputs to a problem, and recommend solutions/preferred options

  • Strong communication skills, including written and oral communication of executive level information and recommendations

  • Ability to provide insight into complex program interdependencies and assist in providing related budget and FTE impact

  • Ability to adapt quickly and well to change, both organizationally and culturally

  • Ability to identify key priorities, align strategic and tactical plans and motivate cross-functional teams and drive effective partnerships across function

Fluency (spoken and written) in English

Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

EEO is the Law -

EEO is the Law – Supplement -

Pay Transparency Policy -

Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.